Collective behaviors of Drosophila-derived retinal progenitors in controlled microenvironments.

ABSTRACT: Collective behaviors of retinal progenitor cells (RPCs) are critical to the development of neural networks needed for vision. Signaling cues and pathways governing retinal cell fate, migration, and functional organization are remarkably conserved across species, and have been well-studied using Drosophila melanogaster. However, the collective migration of heterogeneous groups of RPCs in response to dynamic signaling fields of development remains incompletely understood. This is in large part because the genetic advances of seminal invertebrate models have been poorly complemented by in vitro cell study of its visual development. Tunable microfluidic assays able to replicate the miniature cellular microenvironments of the developing visual system provide newfound opportunities to probe and

SUBMITTER: Pena CD 

PROVIDER: S-EPMC6910854 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature