Effect of Seasonal Malaria Chemoprevention on Immune Markers of Exhaustion and Regulation.

ABSTRACT:

Background

Seasonal malaria chemoprevention (SMC) is a novel strategy to reduce malaria infections in children. Infection with Plasmodium falciparum results in immune dysfunction characterized by elevated expression of markers associated with exhaustion, such as PD1 and LAG3, and regulatory CD4+FOXP3+ T cells.

Methods

In the current study, the impact of seasonal malaria chemoprevention on malaria-induced immune dysfunction, as measured by markers associated with exhaustion and regulatory T cells, was explored by flow cytometry.

Results

Children that received seasonal malaria chemoprevention had fewer malaria episodes and showed significantly lower fold changes in CD4+PD1+ and CD4+PD1+LAG3+ compared to those that did not receive SMC. Seasonal malaria chemoprevention ha

SUBMITTER: Attaher O 

PROVIDER: S-EPMC6910875 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature