Does dysbiotic endometrium affect blastocyst implantation in IVF patients?

ABSTRACT:

Purpose

To analyze the pregnancy outcomes of IVF patients presenting eubiotic or dysbiotic endometrium at the time of embryo transfer and to analyze what bacterial profiles are suitable for embryo implantation.

Methods

Ninety-nine IVF patients under 40 years old undergoing vitrified-warmed blastocyst transfer in HRT cycle had concurrent endometrial microbiome analysis. Samples from the endometrium were taken from the participants at the time of mock transfer; the bacterial profiles at genus level and percentage of lactobacilli in the endometrium of the patients were analyzed.

Results

Thirty-one cases (31.3%) had dysbiotic endometrium. The background profiles, pregnancy rates per transfer (52.9% vs 54.8%), and miscarriage rates (11.1% vs 5.9%) were comparable between p

SUBMITTER: Hashimoto T 

PROVIDER: S-EPMC6910901 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature