Unaltered intravenous prion disease pathogenesis in the temporary absence of marginal zone B cells.

ABSTRACT: Prion diseases are a unique, infectious, neurodegenerative disorders that can affect animals and humans. Data from mouse transmissions show that efficient infection of the host after intravenous (IV) prion exposure is dependent upon the early accumulation and amplification of the prions on stromal follicular dendritic cells (FDC) in the B cell follicles. How infectious prions are initially conveyed from the blood-stream to the FDC in the spleen is uncertain. Addressing this issue is important as susceptibility to peripheral prion infections can be reduced by treatments that prevent the early accumulation of prions upon FDC. The marginal zone (MZ) in the spleen contains specialized subsets of B cells and macrophages that are positioned to continuously monitor the blood-stream and remove pat

SUBMITTER: Bradford BM 

PROVIDER: S-EPMC6910919 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature