Clinical and Genetic Contributors to New-Onset Atrial Fibrillation in Critically Ill Adults.

ABSTRACT:

Objectives

New-onset atrial fibrillation during critical illness is an independent risk factor for mortality. The ability to identify patients at high risk for new-onset atrial fibrillation is limited. We hypothesized that genetic susceptibility contributes to risk of new-onset atrial fibrillation in the ICU.

Design

Retrospective sub-study of a prospective observational cohort study.

Setting

Medical and general surgical ICUs in a tertiary academic medical center.

Patients

One-thousand three-hundred sixty-nine critically ill patients admitted to the ICU for at least 2 days with no known history of atrial fibrillation who had DNA available for genotyping.

Interventions

None.

Measurements and main results

We genotyped 21 single-nucleotide polymorphis

SUBMITTER: Kerchberger VE 

PROVIDER: S-EPMC6910934 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature