Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites.

ABSTRACT: Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to graft versus host disease (GvHD). Recently, it has been demonstrated that the allogeneic immune response might be influenced by external factors such as tissues microenvironment or host microbiota. Here we used high throughput metabolomics to analyze two cohorts of genotypically HLA-identical related recipient and donor pairs. Metabolomic profiles markedly differ between recipients and donors. At the onset of acute GvHD, in addition to host-derived metabolites, we identify significant variation in microbiota-derived metabolites, especially in aryl hydrocarbon receptor (AhR) ligands, bile acids and plasmalogens. Altogeth

SUBMITTER: Michonneau D 

PROVIDER: S-EPMC6910937 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature