Mechanisms of glucocorticoid resistance in hypereosinophilic syndromes.

ABSTRACT:

Background

Glucocorticoids (GC) are considered first-line therapy for most patients with hypereosinophilic syndrome (HES). Although response rates are generally high, many patients require moderate to high doses for control of eosinophilia and symptoms, and up to 15% of patients do not respond at all. Despite this, little is known about the mechanisms of GC resistance in patients with HES.

Objective

To explore the aetiology of GC resistance in HES.

Methods

Clinical data and samples from 26 patients with HES enrolled on a prospective study of GC responsiveness and 23 patients with HES enrolled on a natural history study of eosinophilia for whom response to GC was known were analysed retrospectively. Expression of GC receptor isoforms was assessed by quantitative RT-PCR

SUBMITTER: Stokes K 

PROVIDER: S-EPMC6910955 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature