Scalp EEG spikes predict impending epilepsy in TSC infants: A longitudinal observational study.

ABSTRACT:

Objective

To determine if routine electroencephalography (EEG) in seizure-naive infants with tuberous sclerosis complex (TSC) can predict epilepsy and subsequent neurocognitive outcomes.

Methods

Forty infants 7 months of age or younger and meeting the genetic or clinical diagnostic criteria for tuberous sclerosis were enrolled. Exclusion criteria included prior history of seizures or treatment with antiseizure medications. At each visit, seizure history and 1-hour awake and asleep video-EEG, standardized across all sites, were obtained until 2 years of age. Developmental assessments (Mullen and Vineland-II) were completed at 6, 12, and 24 months of age.

Results

Of 40 infants enrolled (mean age of 82.4 days), 32 completed the study. Two were lost to follow-up and six w

SUBMITTER: Wu JY 

PROVIDER: S-EPMC6910957 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature