Loss of Vimentin Enhances Cell Motility through Small Confining Spaces.

ABSTRACT: The migration of cells through constricting spaces or along fibrous tracks in tissues is important for many biological processes and depends on the mechanical properties of a cytoskeleton made up of three different filaments: F-actin, microtubules, and intermediate filaments. The signaling pathways and cytoskeletal structures that control cell motility on 2D are often very different from those that control motility in 3D. Previous studies have shown that intermediate filaments can promote actin-driven protrusions at the cell edge, but have little effect on overall motility of cells on flat surfaces. They are however important for cells to maintain resistance to repeated compressive stresses that are expected to occur in vivo. Using mouse embryonic fibroblasts derived from wild-type and vim

SUBMITTER: Patteson AE 

PROVIDER: S-EPMC6910987 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature