Human immune cells infiltrate the spinal cord and impair recovery after spinal cord injury in humanized mice.

ABSTRACT: Humanized mice can be used to better understand how the human immune system responds to central nervous system (CNS) injury and inflammation. The optimal parameters for using humanized mice in preclinical CNS injury models need to be established for appropriate use and interpretation. Here, we show that the developmental age of the human immune system significantly affects anatomical and functional outcome measures in a preclinical model of traumatic spinal cord injury (SCI). Specifically, it takes approximately 3-4 months for a stable and functionally competent human immune system to develop in neonatal immune compromised mice after they are engrafted with human umbilical cord blood stem cells. Humanized mice receiving a SCI before or after stable engraftment exhibit significantly differe

SUBMITTER: Carpenter RS 

PROVIDER: S-EPMC6911055 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature