Immunomodulatory effect of Syphacia obvelata in treatment of experimental DSS-induced colitis in mouse model.

ABSTRACT: The ability of helminth parasite infections to manipulate the immune system of their host towards T regulatory responses has been proposed to suppress the inflammatory response. The aim of this study was to investigate the protective and therapeutic effect of Syphacia obvelata in the treatment of experimental DSS -induced colitis. 50 male C57BL/6 mice were divided into 5 groups: healthy uninfected controls, DSS colitis, receiving only S. obv, preventive (S. obv + DSS) and therapeutic group (DSS + S.obv). Colitis intensity was investigated by measuring body weight changes, stool consistency/bleeding and colon length. To evaluate the immune responses induced by this nematode, TNF-α, IL-10, IL-17, IFN-γ and expressing of FoxP3⁺ T cells were measured in mesenteric lymph nodes and Pe

SUBMITTER: Taghipour N 

PROVIDER: S-EPMC6911064 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature