Regulatory networks of circRNAs related to transcription factors in Populus euphratica Oliv. heteromorphic leaves.

ABSTRACT: Circular RNAs (circRNAs) are a novel class of non-coding RNAs that are characterized by a covalently closed circular structure. They have been widely found in Populus euphratica Oliv. heteromorphic leaves (P. hl). To study the role of circRNAs related to transcription factors (TFs) in the morphogenesis of P. hl, the expression profiles of circRNAs in linear, lanceolate, ovate, and broad-ovate leaves of P. euphratica were elucidated by strand-specific sequencing. We identified and characterized 22 circRNAs related to TFs in P. hl at the four developmental stages. Using the competing endogenous RNAs hypothesis as a guide, we constructed circRNA-miRNA-TF mRNA regulatory networks, which indicated that circRNAs antagonized microRNAs (miRNAs), thereby influencing the expression of the miRNA targ

SUBMITTER: Bao L 

PROVIDER: S-EPMC6911160 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature