Helminthostachys zeylanica alleviates hepatic steatosis and insulin resistance in diet-induced obese mice.

ABSTRACT: BACKGROUND:Obesity and its associated health conditions, type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD), are worldwide health problems. It has been shown that insulin resistance is associated with increased hepatic lipid and causes hepatic steatosis through a myriad of mechanisms, including inflammatory signaling. METHODS:Helminthostachys zeylanica (HZ) is used widely as a common herbal medicine to relieve fever symptoms and inflammatory diseases in Asia. In the present study, we evaluated whether HZ has therapeutic effects on obesity, NAFLD and insulin resistance. The protective effects of HZ extract were examined using free fatty acid-induced steatosis in human HuS-E/2 cells and a high-fat diet-induced NAFLD in mice. RESULTS:The major components of the HZ ex

SUBMITTER: Chang TC 

PROVIDER: S-EPMC6911300 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature