Knockdown of SLC35F2 Inhibits the Proliferation and Metastasis of Bladder Cancer Cells.

ABSTRACT:

Background

Many studies have shown that solute carrier family 35 member F2 (SLC35F2) plays a key role in the biological processes of multiple cancers. However, there have been no reports on the role of SLC35F2 in the occurrence and development of bladder cancer (BC).

Methods

SLC35F2 expression data and clinical and prognostic information from BC patients were obtained from databases. SLC35F2 expression in BC was verified by quantitative real-time PCR (qRT-PCR). The influence of SLC35F2 knockdown on the proliferation, apoptosis, migration and invasion in the 5637 and T24 cell lines was studied, and tumor formation experiments were performed in nude mice. Gene set enrichment analysis (GSEA) was used to predict the pathways and functions of SLC35F2 in BC.

Results

SLC35F2

SUBMITTER: Chen M 

PROVIDER: S-EPMC6911351 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature