Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology.

ABSTRACT: Two technologies that have emerged in the last decade offer a new paradigm for modern pharmacology, as well as drug discovery and development. Quantitative systems pharmacology (QSP) is a complementary approach to traditional, target-centric pharmacology and drug discovery and is based on an iterative application of computational and systems biology methods with multiscale experimental methods, both of which include models of ADME-Tox and disease. QSP has emerged as a new approach due to the low efficiency of success in developing therapeutics based on the existing target-centric paradigm. Likewise, human microphysiology systems (MPS) are experimental models complementary to existing animal models and are based on the use of human primary cells, adult stem cells, and/or induced pluripotent

SUBMITTER: Taylor DL 

PROVIDER: S-EPMC6911651 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature