Comparative gene expression analysis in melanocytes driven by tumor cell-derived exosomes.

ABSTRACT: Abundant with organelle-like membranous structures, the tumor microenvironment is composed of cancer cells that secrete exosomes. Studies have shown that these secreted exosomes transport RNA and active molecules to other cells to reshape the tumor microenvironment and promote tumor growth. In fact, we found that exosomes derived from melanoma cells drive pre-malignant transition in primary melanocytes. However, there is little available in the scientific literature on how exosomes modulate melanocytes in the microenvironment to optimize conditions for tumor progression and metastasis. We therefore focused this current study on identifying these conditions genetically. Through RNA sequencing, we analyzed gene expression levels of melanocytes driven by exosomes derived from melanoma and lun

SUBMITTER: Xiao D 

PROVIDER: S-EPMC6911827 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature