Colchicine's effects on lipoprotein particle concentrations in adults with metabolic syndrome: A secondary analysis of a randomized controlled trial.

ABSTRACT:

Background

Colchicine has received renewed interest for its potential beneficial effects in secondary prevention of cardiovascular disease. This was presumed to be primarily because of its anti-inflammatory effects; however, limited data exist regarding colchicine's impact on other cardiovascular risk factors.

Objective

The aim of this study was to examine if colchicine's anti-inflammatory actions would lead to reduced circulating concentrations of oxidized low-density lipoprotein (oxLDL) in metabolically unhealthy individuals. We also examined if colchicine would improve concentrations of other atherogenic lipoprotein subfractions.

Methods

This is a secondary analysis of a double-blind, randomized, placebo-controlled pilot study in which 40 adults with metabolic synd

SUBMITTER: Demidowich AP 

PROVIDER: S-EPMC6911837 | biostudies-literature | 2019 Nov - Dec

REPOSITORIES: biostudies-literature