Increased risk for other cancers in individuals with Ewing sarcoma and their relatives.

ABSTRACT:

Background

There are few reports of the association of other cancers with Ewing sarcoma in patients and their relatives. We use a resource combining statewide genealogy and cancer reporting to provide unbiased risks.

Methods

Using a combined genealogy of 2.3 million Utah individuals and the Utah Cancer Registry (UCR), relative risks (RRs) for cancers of other sites were estimated in 143 Ewing sarcoma patients using a Cox proportional hazards model with matched controls; however, risks in relatives were estimated using internal cohort-specific cancer rates in first-, second-, and third-degree relatives.

Results

Cancers of three sites (breast, brain, complex genotype/karyotype sarcoma) were observed in excess in Ewing sarcoma patients. No Ewing sarcoma patients were ide

SUBMITTER: Abbott D 

PROVIDER: S-EPMC6912049 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature