Assessment of Fractional Factorial Design for the Selection and Screening of Appropriate Components of a Self-nanoemulsifying Drug Delivery System Formulation.

ABSTRACT: Purpose: Recently, a self-nanoemulsifying drug delivery system (SNEDDS) has shown great improvement in the enhancement of drug bioavailability. The selection of appropriate compositions in the SNEDDS formulation is the fundamental step towards developing a successful formulation. This study sought to evaluate the effectiveness of fractional factorial design (FFD) in the selection and screening of a SNEDDS composition. Furthermore, the most efficient FFD approach would be applied to the selection of SNEDDS components. Methods: The types of oil, surfactant, co-surfactant, and their concentrations were selected as factors. 2⁶ full factorial design (FD) (64 runs), 2^6-1 FFD (32 runs), 2^6-2 FFD (16 runs), and 2^6-3 FFD (8 run

SUBMITTER: Kuncahyo I 

PROVIDER: S-EPMC6912180 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature