Urinary Excretion of N¹-Methylnicotinamide, as a Biomarker of Niacin Status, and Mortality in Renal Transplant Recipients.

ABSTRACT: Renal transplant recipients (RTR) commonly suffer from vitamin B₆ deficiency and its functional consequences add to an association with poor long-term outcome. It is unknown whether niacin status is affected in RTR and, if so, whether this affects clinical outcomes, as vitamin B₆ is a cofactor in nicotinamide biosynthesis. We compared 24-h urinary excretion of N¹-methylnicotinamide (N¹-MN) as a biomarker of niacin status in RTR with that in healthy controls, in relation to dietary intake of tryptophan and niacin as well as vitamin B₆ status, and investigated whether niacin status is associated with the risk of premature all-cause mortality in RTR. In a prospective cohort of 660 stable RTR with a median follow-up of 5.4 (4

SUBMITTER: Deen CPJ 

PROVIDER: S-EPMC6912198 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature