Hits Discovery on the Androgen Receptor: In Silico Approaches to Identify Agonist Compounds.

ABSTRACT: The androgen receptor (AR) is a transcription factor that plays a key role in sexual phenotype and neuromuscular development. AR can be modulated by exogenous compounds such as pharmaceuticals or chemicals present in the environment, and particularly by AR agonist compounds that mimic the action of endogenous agonist ligands and whether restore or alter the AR endocrine system functions. The activation of AR must be correctly balanced and identifying potent AR agonist compounds is of high interest to both propose treatments for certain diseases, or to predict the risk related to agonist chemicals exposure. The development of in silico approaches and the publication of structural, affinity and activity data provide a good framework to develop rational AR hits prediction models. Herei

SUBMITTER: Reau M 

PROVIDER: S-EPMC6912550 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature