HIF1α-Dependent Metabolic Signals Control the Differentiation of Follicular Helper T Cells.

ABSTRACT: Follicular helper T (T_FH) cells are critical for germinal center (GC) formation and are responsible for effective B cell-mediated immunity; metabolic signaling is an important regulatory mechanism for the differentiation of T_FH cells. However, the precise roles of hypoxia inducible factor (HIF) 1α-dependent glycolysis and oxidative phosphorylation (OXPHOS) metabolic signaling remain unclear in T_FH cell differentiation. Herein, we investigated the effects of glycolysis and OXPHOS on T_FH cell differentiation and GC responses using a pharmacological approach in mice under a steady immune status or an activated immune status, which can be caused by foreign antigen stimulation and viral infection. GC and T_FH cell responses are related to si

SUBMITTER: Dong L 

PROVIDER: S-EPMC6912655 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature