Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain.

ABSTRACT: Second-generation antipsychotics (SGAs) are the cornerstone of treatment for schizophrenia because of their high clinical efficacy. However, SGA treatment is associated with severe metabolic alterations and body weight gain, which can increase the risk of type 2 diabetes and cardiovascular disease, and greatly accelerate mortality. Several underlying mechanisms have been proposed for antipsychotic-induced weight gain (AIWG), but some studies suggest that metabolic changes in insulin-sensitive tissues can be triggered before the onset of AIWG. In this review, we give an outlook on current research about the metabolic disturbances provoked by SGAs, with a particular focus on whole-body glucose homeostasis disturbances induced independently of AIWG, lipid dysregulation or adipose tissue distu

SUBMITTER: Grajales D 

PROVIDER: S-EPMC6912706 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature