Expression of EEF1A1 Is Associated with Prognosis of Patients with Colon Adenocarcinoma.

ABSTRACT: The prognostic role of the translational factor, elongation factor-1 alpha 1 (EEF1A1), in colon cancer is unclear. The present study aimed to investigate the expression of EEF1A in tissues obtained from patients with stage II and III colon cancer and analyze its association with patient prognosis. A total of 281 patients with colon cancer who underwent curative resection were analyzed according to EEF1A1 expression. The five-year overall survival in the high-EEF1A1 group was 87.7%, whereas it was 65.6% in the low-EEF1A1 expression group (hazard ratio (HR) 2.47, 95% confidence interval (CI) 1.38-4.44, p = 0.002). The five-year disease-free survival of patients with high EEF1A1 expression was 82.5%, which was longer than the rate of 55.4% observed for patients with low EEF1A1 expression (HR

SUBMITTER: Joung EK 

PROVIDER: S-EPMC6912729 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature