MiRNA-29b Inhibits Prostate Tumor Growth and Induces Apoptosis by Increasing Bim Expression.

ABSTRACT: Prostate cancer is one of the most common cancers among men. Currently available therapies improve patient survival against local prostate cancer but have shown severe side effects. Advanced prostate cancer is still incurable. Studies have suggested the involvement of non-coding RNAs, especially micro-RNAs (miRNAs), in the regulation of multiple cellular events in cancer and thus several clinical trials are ongoing using miRNAs mimics or inhibitors. We previously demonstrated that miRNA-29b-3p (miR-29b) was downregulated in prostate cancer and that the overexpression of miR-29b limited prostate cancer metastasis. However, the therapeutic potential of the miR-29b against prostate cancer remains unknown. Here, we evaluated the therapeutic role of miR-29b in in vivo prostate tumors in a mouse

SUBMITTER: Sur S 

PROVIDER: S-EPMC6912792 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature