Autophagic- and Lysosomal-Related Biomarkers for Parkinson's Disease: Lights and Shadows.

ABSTRACT: Parkinson's disease (PD) is a neurodegenerative disorder that currently affects 1% of the population over the age of 60 years, for which no disease-modifying treatments exist. This lack of effective treatments is related to the advanced stage of neurodegeneration existing at the time of diagnosis. Thus, the identification of early stage biomarkers is crucial. Biomarker discovery is often guided by the underlying molecular mechanisms leading to the pathology. One of the central pathways deregulated during PD, supported both by genetic and functional studies, is the autophagy-lysosomal pathway. Hence, this review presents different studies on the expression and activity of autophagic and lysosomal proteins, and their functional consequences, performed in peripheral human biospecimens. Althou

SUBMITTER: Xicoy H 

PROVIDER: S-EPMC6912814 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature