Characterization and Potential Applications of Dog Natural Killer Cells in Cancer Immunotherapy.

ABSTRACT: Natural killer (NK) cells of the innate immune system are a key focus of research within the field of immuno-oncology based on their ability to recognize and eliminate malignant cells without prior sensitization or priming. However, barriers have arisen in the effective translation of NK cells to the clinic, in part because of critical species differences between mice and humans. Companion animals, especially dogs, are valuable species for overcoming many of these barriers, as dogs develop spontaneous tumors in the setting of an intact immune system, and the genetic and epigenetic factors that underlie oncogenesis appear to be similar between dogs and humans. Here, we summarize the current state of knowledge for dog NK cells, including cell surface marker phenotype, key NK genes and geneti

SUBMITTER: Gingrich AA 

PROVIDER: S-EPMC6912828 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature