Rare germline mutations in African American men diagnosed with early-onset prostate cancer.

ABSTRACT:

Background

African Americans have both a higher incidence of prostate cancer and greater disease-specific mortality compared with non-Hispanic whites. Historically, the investigation of the contribution of rare genetic variants to prostate cancer in African American men has been hampered by low participation in large genetic studies, particularly those focused on early-onset and familial disease.

Methods

We sequenced 160 genes purported to be involved in carcinogenic pathways in germline DNA samples collected from 96 African American men diagnosed with early-onset prostate cancer (≤55 years at diagnosis). REVEL software was used to determine the pathogenic potential of observed missense variants.

Results

We observed three protein-truncating mutations, one in BRCA2 and

SUBMITTER: Beebe-Dimmer JL 

PROVIDER: S-EPMC6912854 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature