Unknown

Dataset Information

0

Eighteen 5,7-Dihalo-8-quinolinol and 2,2'-Bipyridine Co(II) Complexes as a New Class of Promising Anticancer Agents.

ABSTRACT: Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2]·(CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2]·CH3OH (Co7), [Co(MDP)(QL1)2]·3H2O (Co8), [Co(ODP)(QL1)2]·CH3OH (Co9), [Co(PPT)(QL1)2]·CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2'-bipyridine mixed ligands. The antitumor activity of Co1-Co18 has been evaluated against human HeLa (cervical) cancer cells in vitro (IC50 values = 0.8 nM-11.88 μM), as well as in vivo against HeLa xenograft tumor growth (TIR = 43.7%, p < 0.05). Importantly, Co7 exhibited high safety in vivo and was more effective in inhibiting HeLa tumor xenograft growth (43.7%) than cisplatin (35.2%) under the same conditions (2.0 mg/kg). In contrast, the H-QL1 and DPPZ ligands greatly enhanced the activity and selectivity of Co7 in comparison to Co1-Co6, Co8-Co18, and previously reported cobalt(II) compounds. In addition, Co7 (0.8 nM) inhibited telomerase activity, caused G2/M phase arrest, and induced mitochondrial dysfunction at a concentration 5662.5 times lower than Co1 (4.53 μM) in related assays. Taken together, Co7 showed low toxicity, and the combination could be a novel Co(II) antitumor compound candidate.

SUBMITTER: Meng T 

PROVIDER: S-EPMC6912862 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Eighteen 5,7-Dihalo-8-quinolinol and 2,2'-Bipyridine Co(II) Complexes as a New Class of Promising Anticancer Agents.

Meng Ting T   Qin Qi-Pin QP   Zou Hua-Hong HH   Wang Kai K   Liang Fu-Pei FP  

ACS medicinal chemistry letters 20191030 12

Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)<sub>2</sub>] (<b>Co1</b>), [Co(py)(QL2)<sub>2</sub>] (<b>Co2</b>), [Co(Phen)(QL1)<sub>2</sub>] (<b>Co3</b>), [Co(Phen)(QL2)<sub>2</sub>] (<b>Co4</b>), [Co(DPQ)(QL1)<sub>2</sub>]·(CH<sub>3</sub>OH)<sub>4</sub> (<b>Co5</b>), [Co(DPQ)(QL2)<sub>2</sub>] (<b>Co6</b>), [Co(DPPZ)(QL1)<sub>2</sub>]·CH<sub>3</sub>OH (<b>Co7</b>), [Co(MDP)(QL1)<sub>2</sub>]·3H<sub>2</  ...[more]

Similar Datasets

Unknown Folate-based binuclear Mn(II) chelates with 2,2'-bipyridine/1,10-phenanthroline as targeted anticancer agents for colon cancer cells.
| S-EPMC12313882 | biostudies-literature
Unknown Ruthenium(II)-Arene Complexes with a 2,2'-Bipyridine Ligand as Anti-Aβ Agents.
| S-EPMC12024814 | biostudies-literature
Unknown Synthesis of [PtCl2(4,4'-dialkoxy-2,2'-bipyridine)] complexes and their in vitro anticancer properties.
| S-EPMC3954779 | biostudies-literature
Unknown Anticancer potential of 2,2'-bipyridine hydroxamic acid derivatives in head and neck cancer therapy.
| S-EPMC12328545 | biostudies-literature
Unknown μ-Oxalato-bis-[bis-(2,2'-bipyridine)-manganese(II)] bis(perchlorate) 2,2'-bipyridine solvate.
| S-EPMC3201320 | biostudies-literature
Unknown 2,2'-Dimethyl-4,4'-bipyridine.
| S-EPMC2961716 | biostudies-literature
Unknown 5,5'-Dimethyl-2,2'-bipyridine.
| S-EPMC2969272 | biostudies-literature
Unknown Tetrasubstituted Pyrrole Derivative Mimetics of Protein-Protein Interaction Hot-Spot Residues: A Promising Class of Anticancer Agents Targeting Melanoma Cells.
| S-EPMC10223356 | biostudies-literature
Unknown New Synthetic Nitro-Pyrrolomycins as Promising Antibacterial and Anticancer Agents.
| S-EPMC7345095 | biostudies-literature
Unknown Taccalonolides: A Novel Class of Microtubule-Stabilizing Anticancer Agents.
| S-EPMC7926778 | biostudies-literature