Early white matter development is abnormal in tuberous sclerosis complex patients who develop autism spectrum disorder.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is prevalent in tuberous sclerosis complex (TSC), occurring in approximately 50% of patients, and is hypothesized to be caused by disruption of neural circuits early in life. Tubers, or benign hamartomas distributed stochastically throughout the brain, are the most conspicuous of TSC neuropathology, but have not been consistently associated with ASD. Widespread neuropathology of the white matter, including deficits in myelination, neuronal migration, and axon formation, exist and may underlie ASD in TSC. We sought to identify the neural circuits associated with ASD in TSC by identifying white matter microstructural deficits in a prospectively recruited, longitudinally studied cohort of TSC infants.

Methods

TSC infants were recruited

SUBMITTER: Prohl AK 

PROVIDER: S-EPMC6912944 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature