Personalized viral genomic investigation of herpes simplex virus 1 perinatal viremic transmission with dual fatality.

ABSTRACT: Here we present a personalized viral genomics approach to investigating a rare case of perinatal herpes simplex virus 1 (HSV-1) transmission that ended in death of both mother and neonate. We sought to determine whether the virus involved in this rare case had any unusual features that may have contributed to the dire patient outcome. A pregnant woman with negative HerpeSelect antibody test underwent cesarean section at 30 wk gestation and died the same day. The premature newborn died 5 d later. Both individuals were found postmortem to have positive blood HSV-1 PCR tests. Using oligonucleotide enrichment and deep sequencing, we determined that viral transmission from mother to infant was nearly perfect at the consensus genome level. At the virus population level, 77% of minor variants (MV

SUBMITTER: Shipley MM 

PROVIDER: S-EPMC6913147 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature