STAT3 speeds up progression of osteoarthritis through NF-κB signaling pathway.

ABSTRACT: Osteoarthritis (OA) is the most common motor system disease in the elderly, with a high incidence and a huge social and economic burden. Therefore, it is urgent to study its potential pathogenesis to improve the therapeutic effect of the disease. In this study, we constructed a number of regulator-mediated OA dysfunction modules, and carried out in-depth analysis in order to examine the disease development process. Differential expression analysis, co-expression analysis and enrichment analysis were combined to screen genes related to disease progression. Subsequently, key regulatory factors in the process of OA were identified based on the pivotal regulators that may manipulate important parts of the module subnetwork. A total of 16 OA dysfunction modules were obtained, involving the aggr

SUBMITTER: Wang F 

PROVIDER: S-EPMC6913305 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature