ABCB1 Polymorphisms and Drug-Resistant Epilepsy in a Tunisian Population.

ABSTRACT:

Background

Epilepsy is one of the most common neurological disorders with about 30% treatment failure rate. An interindividual variations in efficacy of antiepileptic drugs (AEDs) make the treatment of epilepsy challenging, which can be attributed to genetic factors such as ATP-Binding Cassette sub-family B, member1 (ABCB1) gene polymorphisms.

Objective

The main objective of the present study is to evaluate the association of ABCB1 C1236T, G2677T, and C3435T polymorphisms with treatment response among Tunisian epileptic patients.

Materials and methods

One hundred epileptic patients, originated from north of Tunisia, were recruited and categorized into 50 drug-resistant and 50 drug-responsive patients treated with antiepileptic drugs (AEDs) as per the Int

SUBMITTER: Chouchi M 

PROVIDER: S-EPMC6913308 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature