Differentiation of Recurrence from Radiation Necrosis in Gliomas Based on the Radiomics of Combinational Features and Multimodality MRI Images.

ABSTRACT:

Purpose

To classify radiation necrosis versus recurrence in glioma patients using a radiomics model based on combinational features and multimodality MRI images.

Methods

Fifty-one glioma patients who underwent radiation treatments after surgery were enrolled in this study. Sixteen patients revealed radiation necrosis while 35 patients showed tumor recurrence during the follow-up period. After treatment, all patients underwent T1-weighted, T1-weighted postcontrast, T2-weighted, and fluid-attenuated inversion recovery scans. A total of 41,284 handcrafted and 24,576 deep features were extracted for each patient. The 0.623 + bootstrap method and the area under the curve (denoted as 0.632 + bootstrap AUC) metric were used to select the features. The stepwise forward method was ap

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC6913337 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature