Combined effects of age and BMI are related to altered cortical thickness in adolescence and adulthood.

ABSTRACT: Overweight and obesity are associated with functional and structural alterations in the brain, but how these associations change across critical developmental periods remains unknown. Here, we examined the relationship between age, body mass index (BMI) and cortical thickness (CT) in healthy adolescents (n = 70; 14-19 y) and adults (n = 75; 25-45 y). We also examined the relationship between adiposity, impulsivity, measured by delay discounting (DD), and CT of the inferior frontal gyrus (IFG), a region key to impulse control. A significant age-by-BMI interaction was observed in both adolescents and adults; however, the direction of this relationship differed between age groups. In adolescents, increased age-adjusted BMI Z-score attenuated age-related CT reductions globally and in frontal,

SUBMITTER: Westwater ML 

PROVIDER: S-EPMC6913515 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature