Modulation of supramolecular self-assembly of an antimicrobial designer peptide by single amino acid substitution: Implications on peptide activity.

ABSTRACT: Hydrophobicity and charge are key properties of antimicrobial peptides (AMPs). We compared the self-assembly performance and its correlation with antimicrobial activity of a designer AMP and analogues with substitution of hydrophobic or cationic residues by alanine. Peptides that formed supramolecular self-assemblies under the studied conditions were those that have higher antimicrobial potency.

SUBMITTER: Ye Z 

PROVIDER: S-EPMC6913536 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature