Race, APOEɛ4, and Long-Term Cognitive Trajectories in a Biracial Population Sample.

ABSTRACT:

Background

The association of the APOEɛ4 allele with incident Alzheimer's dementia is higher among European Americans (EAs) than African Americans (AAs), but similar for the rate of cognitive decline.

Objective

To examine the racial differences in the association of the APOEɛ4 allele with incident Alzheimer's dementia and cognitive decline.

Methods

Using a population-based sample of 5,117 older adults (66% AAs and 63% females), we identified cognitive trajectory groups from a latent class mixed model and examined the association of the APOEɛ4 allele with these groups.

Results

The frequency of the APOEɛ4 allele was higher among AAs than EAs (37% versus 26%). Four cognitive trajectories were identified: slow, mild, moderate, and rapid. Overall, AAs had a lower ba

SUBMITTER: Rajan KB 

PROVIDER: S-EPMC6914259 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature