Ontology highlight
ABSTRACT:
SUBMITTER: Ma X
PROVIDER: S-EPMC6914388 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Aging 20191127 22
Proper activation of Toll-like receptor (TLR)-mediated signaling and production of proinflammatory cytokines are critical for the initiation of innate immunity, while the specific mechanism maintaining inflammatory homeostasis remains mostly unknown. Here, we show that Ets2 is upregulated following LPS and VSV stimulation. Ets2 knockdown or knockout leads to increased IL-6, TNF-α, and IFN-β production in macrophages. Consistently, Ets2-deficient mice show exacerbated inflammatory cytokine produc ...[more]