A nutrigenetic approach for investigating the relationship between vitamin B12 status and metabolic traits in Indonesian women.

ABSTRACT:

Purpose

Adverse effects of maternal vitamin B12 deficiency have been linked to major clinical outcomes, including increased body mass index and gestational diabetes, however, less is known about vitamin B12 nutrition in non-pregnant women. Hence, the aim of the present study was to explore the relationships between metabolic traits and vitamin B12 status in a cohort of healthy Indonesian women and to investigate whether these relationships were modified by dietary intake using a genetic approach.

Methods

A total of 117 Minangkabau women (aged 25-60 years), from the city of Padang, West Sumatra underwent anthropometric, biochemical, dietary intake analysis and genetic tests. Genetic risk scores (GRS) based on nine vitamin B12 associated single nucleotide polymorphisms (SNPs)

SUBMITTER: Surendran S 

PROVIDER: S-EPMC6914754 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature