Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data.

ABSTRACT: Plant Protection Products, more commonly referred to as pesticides and biocides, are used to control a wide range of yield-reducing pests including insects, fungi, nematodes, and weeds. Concern has been raised that some pesticides may act as endocrine disrupting chemicals (EDCs) with the potential to interfere with the hormone systems of non-target invertebrates and vertebrates, including humans. EDCs act at low doses and particularly vulnerable periods of exposure include pre- and perinatal development. Of critical concern is the number of pesticides with the potential to interfere with the developing nervous system and brain, notably with thyroid hormone signaling. Across vertebrates, thyroid hormone orchestrates metamorphosis, brain development, and metabolism. Pesticide action on thyro

SUBMITTER: Leemans M 

PROVIDER: S-EPMC6915086 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature