Epithelial Cell Adhesion Molecule in Primary Sjogren's Syndrome Patients: Characterization and Evaluation of a Potential Biomarker.

ABSTRACT:

Objective

To determine the subcellular localization of epithelial cell adhesion molecule (EpCAM) in labial salivary gland (LSG) and evaluate the diagnostic use of the extracellular domain of EpCAM (EpEX) and intracellular domain (EpICD) for primary Sjögren's syndrome (pSS).

Methods

Immunohistochemical (IHC) analysis was conducted using EpEX and EpICD domain-specific antibodies on labial salivary gland biopsy (LSGB) from participants. Chi-square or Fisher's exact analysis, Mann-Whitney U-test, and Kruskal-Wallis test compared differences among groups. Independent risk factors of pSS were determined by multiple logistic regression analysis. Receiver-operator characteristic curves (ROC) were carried out to estimate the diagnostic value.

Results

Compared to non-SS

SUBMITTER: Zhang K 

PROVIDER: S-EPMC6915146 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature