Reproducibility of compartmental modelling of ¹⁸F-FDG PET/CT to evaluate lung inflammation.

ABSTRACT:

Introduction

Compartmental modelling is an established method of quantifying ¹⁸F-FDG uptake; however, only recently has it been applied to evaluate pulmonary inflammation. Implementation of compartmental models remains challenging in the lung, partly due to the low signal-to-noise ratio compared to other organs and the lack of standardisation. Good reproducibility is a key requirement of an imaging biomarker which has yet to be demonstrated in pulmonary compartmental models of ¹⁸F-FDG; in this paper, we address this unmet need.

Methods

Retrospective subject data were obtained from the EVOLVE observational study: Ten COPD patients (age =66±9; 8M/2F), 10 α₁ATD patients (age =63±8; 7M/3F) and 10 healthy volunteers (age =68±8; 9M/1F) never smoker

SUBMITTER: Vass LD 

PROVIDER: S-EPMC6915187 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature