The Study of Enhanced High-Intensity Focused Ultrasound Therapy by Sonodynamic N₂O Microbubbles.

ABSTRACT: High-intensity focused ultrasound (HIFU) is a representative non-invasive method of cancer therapy, but its low therapeutic efficacy and risk of damage to surrounding normal tissue hinder its further clinical development and application. Sonodynamic therapy (SDT) kills tumor cells through reactive oxygen molecules produced by sonosensitizers during ultrasound treatment. SDT can enhance HIFU efficacy like microbubbles. In this work, we developed nanoscale N₂O microbubbles (N₂O-mbs) by an improved mechanical oscillation method. These microbubbles showed good biocompatibility and tumor cell binding. The sonosensitivity of the N₂O-mbs was detected both extracellularly and intracellularly through the detection of reactive oxygen species generation. The toxic eff

SUBMITTER: Zhong X 

PROVIDER: S-EPMC6915195 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature