Integrated analysis of gene modulation profile identifies pathogenic factors and pathways in the liver of diabetic mice.

ABSTRACT:

Purpose

Type-2 diabetes mellitus (T2D) is a metabolic disorder that can progress to a serious chronic disease and frequently develops in obese individuals in association with various pathogenic complications that shorten the lifespan of these patients. The liver is an important organ regulating lipid metabolism, which is damaged in both obesity and T2D; however, the specific pathways involved in these pathogenic effects remain unclear. Establishing a suitable animal model that effectively mimics the human biological condition is a critical factor to allow for precise identification of T2D-related genes.

Methods

The KK.Cg-A^y mouse strain is one such model that has offered insight into obesity-related T2D pathogenesis. To comprehensively assess the association betwe

SUBMITTER: Tran TQ 

PROVIDER: S-EPMC6915200 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature