Dataset Information

Synthesis and Antibacterial Properties of Novel ZnMn2O4-Chitosan Nanocomposites.

ABSTRACT: The development of productive antibacterial agents from nontoxic materials via a simple methodology has been an immense research contribution in the medicinal chemistry field. Herein, a sol-gel one-pot reaction was used to synthesize hybrid composites of hausmannite-chitosan (Mn3O4-CS) and its innovative derivative zinc manganese oxide-chitosan (ZnMn2O4-CS). Fixed amounts of CS with different metal matrix w/v ratios of 0.5%, 1.0%, 1.5%, and 2.0% for Mn and Zn precursors were used to synthesize ZnMn2O4-CS hybrid composites. X-ray diffraction analysis indicated the formation of polycrystalline tetragonal-structured ZnMn2O4 with a CS matrix in the hybrids. Fourier-transform infrared spectroscopic analysis confirmed the formation of ZnMn2O4-CS hybrids. Detailed investigations of the surface modifications were conducted using scanning electron microscopy; micrographs at different magnifications revealed that the composites' surface changed depending on the ratio of the source materials used to synthesize the ZnMn2O4-CS hybrids. The antibacterial activity of the Mn3O4-CS and ZnMn2O4-CS composites was tested against various bacterial species, including Bacillus subtilis, Escherichia coli, Salmonella typhi, and Pseudomonas aeruginosa. The zone of inhibition and minimum inhibitory concentration values were deduced to demonstrate the efficacy of the ZnMn2O4-CS nanocomposites as antibacterial agents.

SUBMITTER: Packirisamy RG

PROVIDER: S-EPMC6915490 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Synthesis and Antibacterial Properties of Novel ZnMn2O4-Chitosan Nanocomposites.

Packirisamy Rajiv Gandhi RG Govindasamy Chandramohan C Sanmugam Anandhavelu A Karuppasamy K K Kim Hyun-Seok HS Vikraman Dhanasekaran D

Nanomaterials (Basel, Switzerland) 20191109 11

The development of productive antibacterial agents from nontoxic materials via a simple methodology has been an immense research contribution in the medicinal chemistry field. Herein, a sol-gel one-pot reaction was used to synthesize hybrid composites of hausmannite-chitosan (Mn3O4-CS) and its innovative derivative zinc manganese oxide-chitosan (ZnMn2O4-CS). Fixed amounts of CS with different metal matrix w/v ratios of 0.5%, 1.0%, 1.5%, a ...[more]

PMID: 31717589

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Project description:Two novel samples of nanoparticles based on chitosan were greenly synthesized using pomegranate peel extract. The extract served as a nanoparticle precursor, facilitating the precipitation of nanosized chitosan through the ionic gelation method. Additionally, by mixing the green chitosan nanoparticles with copper ions, a nanoscale composite of chitosan and copper oxide was also produced. Structural and morphological investigations (FTIR, XRD, SEM, EDX, and TGA analyses) were performed for greenly synthesized chitosan nanoparticles and their copper oxide composite to determine all the significant characteristics of those nanoparticles. In addition, both samples were tested using some biological investigations, such as antimicrobial activity and hematological effects. The antimicrobial tests yielded promising results for both the green chitosan nanoparticles and the CuO composite when tested using two bacterial strains and two fungal strains. Moreover, the results showed that using a similar concentration of both green-based chitosan samples resulted in a slightly larger inhibition zone and a lower minimum inhibition concentration (MIC) for the copper oxide chitosan composite compared to the chitosan nanoparticles for all microorganisms included in the test. The mean count of blood components (RBCs and platelets), clotting time, and cholesterol levels in three different blood samples were used to indicate the hematological activity of both greenly synthesized nanoparticles. The results verified a slight reduction in blood component count after the addition of green chitosan nanoparticles, but the chitosan copper oxide composite did not have a noticeable effect on the three blood samples. The chitosan nanoparticles were able to cause a considerable reduction in clotting time and cholesterol levels for all blood samples, thus acting as procoagulants. However, the mixing of CuO with chitosan nanoparticles prolonged the rate of clotting in blood samples from hypercholesteremic individuals, and thus, the mixture acted as an anticoagulant agent.

Dataset Information

Synthesis and Antibacterial Properties of Novel ZnMn2O4-Chitosan Nanocomposites.

Publications

Synthesis and Antibacterial Properties of Novel ZnMn<sub>2</sub>O<sub>4</sub>-Chitosan Nanocomposites.

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