Parameters Influencing Cavitation Within Vials Subjected to Drop Shock.

ABSTRACT: The pharmaceutical industry has made improvements to mitigate protein degradation during the drug manufacturing process, storage, and transportation. However, there is less quality control after the manufacturer releases the drug. Previous research has shown that drop shock due to mishandling and accidental dropping of therapeutic vials may cause cavitation, aggregation, and particle formation. In this study, the cavitation behavior of Deionized (DI) water and 10mM L-Histidine buffer solution which were subjected to drop shock by hand dropping were investigated to study the effects of vial materials, solutions, fill volumes, drop heights, and internal vial geometries. A Phantom v7 high-speed camera was used to record images at a rate of 66,700 frames per second of the vials as they underwe

SUBMITTER: Valotta Rodrigues R 

PROVIDER: S-EPMC6915723 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature