Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model.

ABSTRACT: A primary cilium is an antenna-like structure on the cell surface that plays a crucial role in sensory perception and signal transduction. Mitochondria, the 'powerhouse' of the cell, control cell survival, and death. The cellular ability to remove dysfunctional mitochondria through mitophagy is important for cell survival. We show here that mitochondrial stress, caused by respiratory complex inhibitors and excessive fission, robustly stimulates ciliogenesis in different types of cells including neuronal cells. Mitochondrial stress-induced ciliogenesis is mediated by mitochondrial reactive oxygen species generation, subsequent activation of AMP-activated protein kinase and autophagy. Conversely, abrogation of ciliogenesis compromises mitochondrial stress-induced autophagy, leading to enhanc

SUBMITTER: Bae JE 

PROVIDER: S-EPMC6915731 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature