MeinteR: A framework to prioritize DNA methylation aberrations based on conformational and cis-regulatory element enrichment.

ABSTRACT: DNA methylation studies have been reformed with the advent of single-base resolution arrays and bisulfite sequencing methods, enabling deeper investigation of methylation-mediated mechanisms. In addition to these advancements, numerous bioinformatics tools address important computational challenges, covering DNA methylation calling up to multi-modal interpretative analyses. However, contrary to the analytical frameworks that detect driver mutational signatures, the identification of putatively actionable epigenetic events remains an unmet need. The present work describes a novel computational framework, called MeinteR, that prioritizes critical DNA methylation events based on the following hypothesis: critical aberrations of DNA methylation more likely occur on a genomic substrate that is

SUBMITTER: Malousi A 

PROVIDER: S-EPMC6915744 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature