Association Between Cardiac Natriuretic Peptides and Lipid Profile: a Systematic Review and Meta-Analysis.

ABSTRACT: Cardiac natriuretic peptides (NPs) play a fundamental role in maintaining cardiovascular (CV) and renal homeostasis. Moreover, they also affect glucose and lipid metabolism. We performed a systematic review and meta-analysis of studies investigating the association of NPs with serum lipid profile. A PubMed and Scopus search (2005-2018) revealed 48 studies reporting the association between NPs and components of lipid profile [total cholesterol (TC), low-density lipoprotein cholesterol (LDLc), high-density lipoprotein cholesterol (HDLc) and triglycerides (TG)]. Despite high inconsistency across studies, NPs levels were inversely associated with TC [k = 32; pooled r = -0.09; I² = 90.26%], LDLc [k = 31; pooled r = -0.09; I² = 82.38%] and TG [k = 46; pooled r = -0.11; I

SUBMITTER: Spannella F 

PROVIDER: S-EPMC6915780 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature