Deciphering retinal diseases through the generation of three dimensional stem cell-derived organoids: Concise Review.

ABSTRACT: Three-dimensional (3D) retinal organoids, in vitro tissue structures derived from self-organizing cultures of differentiating human embryonic stem cells or induced pluripotent stem cells, could recapitulate some aspects of the cytoarchitectural structure and function of the retina in vivo. 3D retinal organoids display huge potential for the investigation of the pathogenesis of monogenic hereditary eye diseases that are related to the malfunction or degeneration of photoreceptors or retinal ganglion cells by providing an effective in vitro tool with multiple applications. In combination with recent genome editing tools, 3D retinal organoids could also represent a reliable and renewable source of transplantable cells for personalized therapies. In this review, we describe the recent advances

SUBMITTER: Artero Castro A 

PROVIDER: S-EPMC6915910 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature